Aqueous zinc-ion batteries (AZIBs) have attracted significant attention due to their high energy density, low cost, high efficiency, and environmental friendliness. Nevertheless, the development of AZIBs has been significantly hindered by the unavoidable issues with zinc dendrites and the side reactions of the anode. The strategies for stable and controllable interfacial regulation have recently made rapid progress, due to their dual function of improving zinc ion transport dynamics and preventing direct contact of zinc with electrolytes. Therefore, it’s imperative to conduct a comprehensive summary of the interfacial regulation of zinc anodes and to engage in in-depth research into the underlying mechanisms. Subsequently, the interfacial regulation was classified based on battery structure, including anode coating strategy, electrolyte engineering, and separator optimization. Eventually, the current limitations of interfacial regulation and a deep outlook on AZIBs interface engineering are summarized.