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Willy W.L. See, Phuc T.T. Nguyen, Heng Yih Tan, Jie Fu Jeff Zhou, Sie Shing Wong, Kang Zhou, Ning Yan. CdS-Enzyme Composite Promotes Photobiocatalytic Conversion of Plastic-derived Lactate to Chiral Chemicals. Green Energy&Environment. doi: 10.1016/j.gee.2025.07.018
Citation: Willy W.L. See, Phuc T.T. Nguyen, Heng Yih Tan, Jie Fu Jeff Zhou, Sie Shing Wong, Kang Zhou, Ning Yan. CdS-Enzyme Composite Promotes Photobiocatalytic Conversion of Plastic-derived Lactate to Chiral Chemicals. Green Energy&Environment. doi: 10.1016/j.gee.2025.07.018
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CdS-Enzyme Composite Promotes Photobiocatalytic Conversion of Plastic-derived Lactate to Chiral Chemicals

doi: 10.1016/j.gee.2025.07.018

  • a. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore;

  • b. Joint School of National University of Singapore and Tianjin University, Fuzhou 350207, Fujian, China;

  • c. Centre for Hydrogen Innovations, National University of Singapore, Singapore 117580, Singapore;

  • d. Cluster of Food, Chemical and Biotechnology, Singapore Institute of Technology, 138683, Singapore

Funds:

We thank MOE Tier-2 project (MOE-T2EP10221-0020) from Ministry of Education, Singapore and the National Research Foundation, Singapore, NRF Investigatorship (NRFI07–2021–0015) for the financial support.

  • Received date 12 April 2025, Accepted date 23 July 2025, RevRecd date 23 July 2025, Available online 02 August 2025
    Abstract
  • The combination of photo- and bio-catalysis in one-pot enables sustainable, visible-light driven cascade reactions for the synthesis of value-added chiral chemicals under mild conditions. Despite the attractiveness of merging the redox capability of heterogeneous photocatalysts with the excellent enantioselectivity of enzymes, developing such reaction under one-pot conditions poses a challenge due to catalyst incompatibility. In this study, a cadmium sulfide (CdS)-enzyme composite was engineered for one-pot conversion of plastic-derived lactate into chiral compounds. By coating CdS onto alginate beads, its redox capability for the oxidation of lactate in water under visible light was preserved. The generated pyruvate subsequently underwent enantioselective transformation catalyzed by encapsulated enzymes within the beads, producing (R)-acetoin, L-alanine, or (R)-phenylacetylcarbinol. The core-shell structure of the CdS-enzyme composite protects the enzymes against radical attacks and also facilitates recycling, with 81% yield of (R)-acetoin achieved after four reaction cycles. Additionally, we demonstrated an upcycling process converting post-consumer polylactic acid cups into (R)-acetoin. This work introduces a novel approach for integrating photocatalysts and enzymes to synthesize chiral chemicals from end-of-life plastics.

     

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