Volume 6 Issue 2
Apr.  2021
Turn off MathJax
Article Contents
Rosaria Ciriminna, Mario Pagliaro, Rafael Luque. Heterogeneous catalysis under flow for the 21st century fine chemical industry. Green Energy&Environment, 2021, 6(2): 161-166. doi: 10.1016/j.gee.2020.09.013
Citation: Rosaria Ciriminna, Mario Pagliaro, Rafael Luque. Heterogeneous catalysis under flow for the 21st century fine chemical industry. Green Energy&Environment, 2021, 6(2): 161-166. doi: 10.1016/j.gee.2020.09.013

Heterogeneous catalysis under flow for the 21st century fine chemical industry

doi: 10.1016/j.gee.2020.09.013
  • Due to metal leaching and poor catalyst stability, the chemical industry's fine chemical and pharmaceutical sectors have been historically reluctant to use supported transition metal catalysts to manufacture fine chemicals and active pharmaceutical ingredients. With the advent of new generation supported metal catalysts and flow chemistry, we argue in this study, this situation is poised to quickly change. Alongside heterogenized metal nanoparticles, both single-site molecular and single-atom catalyst will become ubiquitous. This study offers a critical outlook taking into account both technical and economic aspects.

     

  • loading
  • [1]
    S. Hubner, J. G. de Vries, V. Farina, Why Does Industry Not Use Immobilized Transition Metal Complexes as Catalysts?, Adv. Synth. Catal. 2015, 358, 634-641.
    [2]
    N. End, K.-U. Schoning, Immobilized Catalysts in Industrial Research and Application, In Immobilized Catalysts: Solid Phases, Immobilization and Applications, Volume 242, A. Kirschning (Ed.), Springer, Berlin: 2004; pp. 241-271.
    [3]
    Biotage, Biotage® PS-PPh3-Pd, www.biotage.com/product-page/biotage-ps-pph3-pd
    [4]
    K. Skowerski, J. Pastva, S. J. Czarnocki, J. Janoscova, Exceptionally Stable and Efficient Solid Supported Hoveyda-Type Catalyst, Org. Process Res. Dev. 2015, 19, 872-877.
    [5]
    R. Ciriminna, V. Pandarus, A. Fidalgo, L. M. Ilharco, F. Beland, M. Pagliaro, SiliaCat: A Versatile Catalyst Series for Synthetic Organic Chemistry, Org. Process Res. Devel. 2015, 19, 755-768.
    [6]
    PhosphonicS Introduces Phos-Cat4 Catalyst, chemicalprocessing.com, 2015. See at the URL: www.chemicalprocessing.com/vendors/products/2015/phosphonics-introduce-phos-cat4-catalyst/
    [7]
    P. Pollak, Fine Chemicals: The Industry and the Business, 2nd Edition, Wiley, New York: 2011.
    [8]
    IAL Consultants, Global Overview of the Flavours and Fragrances Market 2018, London: 2018.
    [9]
    J. Hilton, Growth patterns and emerging opportunities in nutraceutical and functional food categories: market overview, In Developing New Functional Food and Nutraceutical Products, Academic Press, New York: 2017; pp. 1-28.
    [10]
    C. Senanayake, cited in: C. A. Challener, Catalysis, Flow Chemistry Impact API Manufacturing, pharmtech.com, 2 May 2017.
    [11]
    C. Wiles, 10 Years of Flow Chemistry: - From an R&D Concept to Implementation at an Industrial Scale, 10th Symposium on Continuous Flow for Industrial Applications, Milano, 13-14 November 2018
    [12]
    K. Masuda, T. Ichitsuka, N. Koumura, K. Sato, S. Kobayashi, Flow fine synthesis with heterogeneous catalysts, Tetrahedron 2018, 74, 1705-1730.
    [13]
    W. Bonrath, New Trends in (Heterogeneous) Catalysis for the Fine Chemicals Industry, Chimia 2014, 68, 485-491.
    [14]
    Evonik, Evonik catalysts for flow chemistry, Essen (Germany): 2018. See at the URL: https://catalysts.evonik.com/product/catalysts/downloads/evonik_flyer_flow_chemistry_e_web.pdf
    [15]
    K. Stott, Pharma’s broken business model: An industry on the brink of terminal decline, Endpoint News, 28 November 2017. See at the URL: https://endpts.com/pharmas-broken-business-model-an-industry-on-the-brink-of-terminal-decline/
    [16]
    R. Ciriminna, M. Pagliaro, Green Chemistry in the Fine Chemicals and Pharmaceutical Industries, Org. Process Res. Devel. 2013, 17, 1479-1484.
    [17]
    R. A. Sheldon, The E factor 25 years on: the rise of green chemistry and sustainability, Green Chem. 2017,19, 18-43.
    [18]
    R. Ciriminna, E. Falletta, C. Della Pina, J. H. Teles, M. Pagliaro, Industrial Applications of Gold Catalysis, Angew. Chem. Int. Ed. 2016, 55, 14210-14217.
    [19]
    C. A. Busacca, D. R. Fandrick, J. J. Song, C. H. Senanayake, “Transition Metal Catalysis in the Pharmaceutical Industry” In Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective, M. L. Crawley, B. M. Trost (Ed.), John Wiley & Sons, New York: 2012; pp.1-24.
    [20]
    S. Bose (Sun Pharma), Lean Perspective of Process Intensification, IGCW 2017, Mumbai, 5-6 October 2017.
    [21]
    F. Sieckmann, H. Nguyen Ngo, R. Helm, H. Kohl, Implementation of lean production systems in small and medium-sized pharmaceutical enterprises, Procedia Manuf. 2018, 21, 814-821.
    [22]
    a) For Instance: Scientific Update Catalysis in the Fine Chemicals Industry - Cutting Edge Development and Industrial Applications Lucerne (2019),pp. 14-15 b) Royal Society of Chemistry Challenges in Catalysis for Pharmaceuticals and Fine Chemicals VI London (2018)
    [23]
    N. G. Anderson, Practical Use of Continuous Processing in Developing and Scaling Up Laboratory Processes, Org. Process Res. Devel., 2001, 5, 613-621.
    [24]
    F. Nerozzi, Heterogeneous Catalytic Hydrogenation, Platinum Met. Rev. 2012, 56, 236-241.
    [25]
    W. Zhao, Make the chemical industry clean with green chemistry: an interview with Buxing Han, Natl. Sci. Rev. 2018, 5, 953-956.
    [26]
    A. Jana, K. Grela, Forged and fashioned for faithfulness-ruthenium olefin metathesis catalysts bearing ammonium tags, Chem. Commun. 2018, 54, 122-139.
    [27]
    Z. Chen, E. Vorobyeva, S. Mitchell, E. Fako, M. A. Ortuno, N. Lopez, S. M. Collins, P. A. Midgley, S. Richard, G. Vile, J. Perez-Ramirez, A heterogeneous single-atom palladium catalyst surpassing homogeneous systems for Suzuki coupling, Nat. Nanotechnol. 2018, 13, 702-707.
    [28]
    Prof. J. Perez-Ramirez (ETH Zurich), personal correspondence with M.P, 15 September 2018.
    [29]
    See at the URL: http://karolgrela.eu/teamtech.
    [30]
    K. Grela, University of Warsaw, Personal correspondence with M.P, 2018. https://www.researchgate.net/profile/Karol-Grela.
    [31]
    R. Ciriminna, M. Ghahremani, B. Karimi, R. Luque, M. Pagliaro, Single-Atom Catalysis: A Practically Viable Technology?, Curr. Op. Green Sust. Chem. 2020, 25, 100358.
    [32]
    Deloitte CIS Research Centre, Russian Pharmaceutical Market Trends in 2018, Moscow: 2018. See at the URL: https://www2.deloitte.com/content/dam/Deloitte/ru/Documents/life-sciences-health-care/russian-pharmaceutical-market-trends-2018-en.pdf
    [33]
    S. A. Yakukhnov, E. O. Pentsak, K. I. Galkin, R. M. Mironenko, V. A. Drozdov, V. A. Likholobov, V. P. Ananikov, Rapid “Mix-and-Stir” Preparation of Well-Defined Palladium on Carbon Catalysts for Efficient Practical Use, ChemCatChem 2018, 10, 1869-1873.
    [34]
    P. Sabatier, The Method of Direct Hydrogenation by Catalysis, Nobel Lecture, December 11, 1912
    [35]
    W. S. Knowles, M. J. Sabacky, Catalytic asymmetric hydrogenation employing a soluble, optically active, rhodium complex, Chem. Commun. 1968, 1445-1446.
    [36]
    R. R. Schrock, Multiple Metal-Carbon Bonds for Catalytic Metathesis Reactions, Nobel Lecture, 8 December 2005.
    [37]
    The Nobel Foundation, The Nobel Prize in Chemistry 2010, www.nobelprize.org/prizes/chemistry/2010/summary.
    [38]
    R. Ciriminna, M. Pagliaro, Industrial Oxidations with Organocatalyst TEMPO and its Derivatives, Org. Process Res. Devel. 2010, 14, 245-251.
    [39]
    G. Samburski, Anelli's (TEMPO) Oxidation of alcohol by flow chemistry, industrial scale, The 80th Annual Meeting of the Israel Chemical Society, Tel Aviv, 17-18 February 2015.
    [40]
    M. C. Bryan, P. J. Dunn, D. Entwistle, F. Gallou, S. G. Koenig, J. D. Hayler, M. R. Hickey, S. Hughes, M. E. Kopach, G. Moine, P.l Richardson, F. Roschangar, A. Steven, F. J. Weiberth, Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited, Green Chem. 2018, 20, 5082-5103.
    [41]
    J. Britton, S. Majumdar, G. A. Weiss, Continuous flow biocatalysis, Chem. Soc. Rev. 2018, 47, 5891-5918.
    [42]
    B. Karimi, M. Ghahremani, R. Ciriminna, M. Pagliaro, New Stable Catalytic Electrodes Functionalized with TEMPO for the Waste-Free Oxidation of Alcohols, Org. Process Res. Devel. 2018, 22, 1298-1305.
    [43]
    R. Ciriminna, R. Delisi, Y.-J. Xu, M. Pagliaro, Towards the Waste-Free Synthesis of Fine Chemicals with Visible Light, Org. Process Res. Devel. 2016, 20, 403-408.
    [44]
    V. V. Ranade, S. S. Joshi, Catalysis and Catalytic Processes, In Industrial Catalytic Processes for Fine and Specialty Chemicals, V. V. Ranade and S. S. Joshi (Ed. s), Elsevier, Amsterdam: 2016; pp. 1-14.
    [45]
    C. Yang, R. Li, K. A. I. Zhang, W. Lin, K. Landfester, X. Wang, Heterogeneous photoredox flow chemistry for the scalable organosynthesis of fine chemicals, Nat. Comm. 2020, 11, 1239.
    [46]
    B. Poznansky, L. A. Thompson, S. A. Warren, H. A. Reeve, K. A. Vincent, Carbon as a Simple Support for Redox Biocatalysis in Continuous Flow, Org. Process Res. Dev. DOI: 10.1021/acs.oprd.9b00410.
    [47]
    M. Pagliaro, An industry in transition: The chemical industry and the megatrends driving its forthcoming transformation, Angew. Chem. Int. Ed. 2019, 58, 11154-11159.
    [48]
    K. F. Jensen, Flow chemistry - microreaction technology comes of age, AIChE J. 2017, 63, 858-869.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (178) PDF downloads(18) Cited by()
    Proportional views

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return